Q.1.
Which one of the following factors related to protein-drug binding is not related to drugs?
- a) Physicochemical characteristics of a drug
- b) The concentration of the drug in the body
- c) The affinity of the drug for binding
- d) Number of binding sites on the binding agent
Q.2.
Which one of the following factor related to protein-drug binding is not related to drug interactions with the binding site?
- a) Competition between the drug and the binding site
- b) Competition between drugs and normal body constituents
- c) Allosteric changes in a protein molecule
- d) Inter subject variation
Q.3.
Which of the following factors for protein drug binding is a drug interaction factor?
- a) Competition between drugs for the binding site
- b) Age
- c) Physicochemical characteristics of a drug
- d) Physicochemical characteristics of the protein or binding agent
Q.4.
Which drugs bind to HSA easily?
- a) Cationic drug
- b) Anionic drug
- c) Lipophilic drug
- d) Neutral drug
Q.5.
Which drugs easily bind to adipose tissue?
- a) Cationic drug
- b) Anionic drug
- c) Lipophilic drug
- d) Neutral drug
Q.6.
Which drug easily bind to AAG?
- a) Cationic drug
- b) Anionic drug
- c) Lipophilic drug
- d) Neutral drug
Q.7.
The extent of drug-protein binding can change with both changes in protein and drug concentration.
- a) True
- b) False
Q.8.
In the equation X= Vd C, what does X stands for?
- a) Amount of drug in the blood
- b) Amount of drug in plasma
- c) Amount of drug in the tablet
- d) Amount of drug in the body
Q.9.
Only unbound or free drug is capable of being eliminated.
- a) True
- b) False
Q.10.
Penicillin has short plasma half-life although it can bind to plasma protein rigidly.
- a) True
- b) False
Q.11.
What kind of graph is shown in the picture?
- a) Direct plot
- b) Scatchard plot
- c) Double reciprocal plot
- d) Michele’s menten plot
Q.12.
What kind of graph is shown in the picture?
- a) Direct plot
- b) Scatchard plot
- c) Double reciprocal plot
- d) Michele’s menten plot
Q.13.
What kind of graph is shown in the picture?
- a) Direct plot
- b) Scatchard plot
- c) Double reciprocal plot
- d) Michele’s menten plot
Q.14.
Displacement interactions are significant in the case of drugs which are more thanbound.
- a) True
- b) False
Q.15.
Which of the following is a correct method to find the fraction of unbound drug in plasma? Given where Cu is the concentration of unbound drug and C is total plasma drug concentration.
- a) CuC
- b) C / Cu
- c) Cu/C
- d) 1/C Cu