Absorption of drugs can be categorized into 2 classes, physicochemical properties of drugs and Dosage form of the drug, on the basis of drug dissolution.
a) True
b) False
Q.2.
Which option will be the best example of the physicochemical properties of drugs?
a) Solubility, particle size, polymorphism, salt form, pseudopolymorphism, complexation, wettability, pH, Pressure of disintegration
b) Pressure of disintegration, polymorphism, salt form, pseudopolymorphism, complexation, wettability, pH
c) Solubility, particle size, polymorphism, salt form
d) Solubility, particle size, polymorphism, salt form, pseudopolymorphism, complexation, wettability
Q.3.
For oral formulation, what should be the minimum aqueous solubility to avoid bioavailability problems?
a) 0.9%
b) 1%
c) 2%
d) 0.11%
Q.4.
The total solid surface area of any particle is known as ___________
a) Absolute surface area
b) Effective surface area
c) Total surface area
d) Surface area
Q.5.
Particle size and surface area of a drug are directly related to each other.
a) True
b) False
Q.6.
Absolute surface area is proportional to the dissolution rate of a drug.
a) True
b) False
Q.7.
In the case of hydrophobic drugs, micronization results in a decrease in effective surface area and thus fall is dissolution rate. Which of the below sentences cannot be a reason for the given statement?
a) The hydrophobic surface of the drugs adsorbs onto their surface which inhibits their wettability
b) The particles reaggregate to form larger particles due to their high surface free energy
c) Extreme reduction in the particle size imparts surface charges that may prevent wetting
d) Extreme reduction in the size brings the hydrophobic amino acids to the surface
Q.8.
How the absolute surface area of hydrophobic drugs can be converted to their effective surface area?
a) Use of surfactant
b) Use of Hydrophobic diluents
c) Use of surfactant and hydrophilic diluents
d) No need of doing micronization
Q.9.
Which one of these is not an example of hydrophilic diluents?
a) PVC
b) Dextrose
c) PVP
d) PEG
Q.10.
The solvate can exist in different crystalline forms called as _________
a) Solvates
b) Pseudopolymorphs
c) Pseudopolymorphism
d) Hydrate
Q.11.
Which form of a drug has greater solubility?
a) Anhydrous
b) Hydrate
c) Crystallised
d) Monohydrate
Q.12.
Which one will be the easiest approach to enhance the solubility and dissolution of any drug?
a) Micronize the drug
b) Convert drug into their anhydrous form
c) Convert drug into their hydrous form
d) Convert drug into their salt form
Q.13.
What is pH?
a) –ve log of H+ concentration
b) +ve log of H+ concentration
c) Log of H+ concentration
d) H+ concentration
Q.14.
Which one of these is not an advantage of buffered aspirin tablets?
a) Enhanced bioavailability
b) Reduced gastric irritation
c) Increased stability
d) Increased ulcerogenic tendency
Q.15.
Larger the size of the counterion, greater the solubility.
a) True
b) False
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